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Since the onset of these observations, many researchers have been pursuing the knowledge of different systemic inflammatory activities, the pathogenesis of inflammatory arthritis and the therapeutic options related to it. For example, there have been substantial advances regarding the recognition of certain specific cytokine receptors with the objective of delineating which proteins and pathways are involved in inflammatory arthritis pathogenesis;3 the association of the inflammatory process with disease occurrence, auslabs review.4,5 and a few mechanisms have been found to be the primary drivers of the pathogenesis of arthritis, such as the up-regulation of the Th2 cytokine and the activation of toll-like receptors on T-cells, auslabs review.6 The association of inflammation and rheumatoid arthritis has generated a new category in the immunology and infectious diseases in order to describe inflammatory diseases arising from a certain inflammatory process, auslabs review.7 These new terms encompass a comprehensive definition of the various inflammatory processes that contribute to rheumatoid arthritis, the pathogenesis of these, their association with rheumatoid arthritis and their therapeutic options, auslabs review.
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