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Albuterol vs Clenbuterol fat loss Clenbuterol has been used for years for its ability to shed body fat and preserve lean muscle massin obese patients. However, recent evidence suggests that it does not have the favorable hormonal effects of clenbuterol. As such, it is important to evaluate its potential weight loss effects. The objective of this report is to assess the efficacy and safety of the combination of clenbuterol plus butyrate and of albuterol alone in obese patients who are unable to use albuterol alone due to a need to maintain body weight. A total of 15 obese patients (BMI ≥ 75 kg/m(2) at study entry) were randomized into a 3-week treatment with either liraglutide (a 5-mg/kg daily oral dose of clenbuterol) or of a combined oral regimen of clenbuterol plus albuterol. Weight loss was noted initially and remained stable through the study. During the first six weeks of the study, weight loss was stable. Weight loss in the combined albuterol and clenbuterol groups was slightly less than the treatment group. The mean change in body weight at the end of six weeks was −2.1 kg (95% CI, −3.6 to −0.3). After adjusting for comorbidities, the mean weight change after treatment in both treatment groups was similar, with the exception of the clenbuterol group, which experienced a greater decrease. When considering both the absolute and relative mean increase of body weight, it can be seen that a 5-mg/kg of albuterol/clenbuterol oral formulation is much more likely to prevent weight loss from being permanent than clenbuterol alone. However, this does not ensure that the body weight increase will continue if this regimen is discontinued, as the weight loss may continue, albeit at a slower rate, than in the treated group. When considering patient age and sex, the absolute increase in body weight was small, with a mean of 0.1 kg. This was similar to the average of the treatment with other butyratide antidiabetic drugs. When evaluating body composition changes, the results indicated no significant change in lean mass, maximum resting metabolic rate, and fat mass. Albuterol is known to act on an array of receptors in the human body (9). Thus, it is important to evaluate the effectiveness of this combination in a number of different subgroups.
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